Among 926 men undergoing hormone therapy for advanced prostate therapy, those taking statins saying significant further, researchers said. Their cancer remained stable for an average of 27.5 months by now worsening, compared following an average of 17.4 months in the midst of men not taking statins.
These findings are preliminary, hence I would not recommend that everybody begin concerning statins to slow prostate cancer, said psychiatry senior author Dr. Philip Kantoff, chief of sealed tumor oncology at the Dana-Farber Cancer Institute in Boston.
Also, Kantoff cautioned that these findings apply isolated to men who have campaigner prostate cancer that has relapsed after hormone therapy.
This does not adopt in the future stage prostate cancer or whether statins are beneficial in preventing prostate cancer, he said.
Patients in the psychoanalysis, conducted from 1996 to 2013, were followed for coarsely speaking six years upon average. The bank account was published May 7 online in JAMA Oncology.
Hormone therapy is the all right treatment for men who strive from prostate cancer that has shape to the lead more than the prostate gland. The therapy deprives the body of testosterone, the male hormone that helps cancer cells ensue. However, greater than era, the therapy becomes less functional and the cancer begins to ensue again.
Essentially, Kantoff explained, statins save testosterone from entering cancer cells. They block dehydroepiandrosterone sulfate (DHEAS), a precursor of testosterone, therefore preventing cancer cell layer, he said.
More specifically, lab experiments indicated that statins use taking place the to hand supply of a protein called SLCO2B1, which allows various drugs and hormones to enter cells. This appears to maintenance DHEAS from the cancer cells, making hormone therapy more functional.
This is a plausible mechanism by which a statin may have a gain to prostate cancer patients, Kantoff said.
Kantoff optional postscript that more studies are needed to tune their findings. We have a sound hypothesis, but it is by no means proof that statins prolong the time to relapse. But the data is strongly suggestive that thats the fact, he said.
Adding a statin to hormone therapy may be a habit to make hormone therapy last longer and prevent cancer from progressing, Kantoff said.
Dr. Jorge Ramos, a hematology and oncology fellow at the University of Washington/Fred Hutchinson Cancer Research Center, discussed the examines relevance.
Other studies have suggested that statins might have a role in preventing cancer or reducing the risk of dying from cancer, he said.
This laboratory analysis suggests how statins might achievement in slowing the augment on of cancer, said Ramos, co-author of an editorial accompanying the chemical analysis. Statins by themselves probably wont prevent cancer from growing, but in combinations considering than added treatments could tote going on outcomes for patients, said .
However, Ramos certainly clinical trials are needed back people begin taking statins to prevent or slow cancer.
Several trials are getting underway to test the benefits of statins in prostate cancer patients, Ramos said. But the results wont be straightforward for several years, he said.
For now, current data is insufficient to part taking statins to prevent prostate cancer or to living longer if you have it, Ramos said.
In the United States, its estimated that one in seven men will manufacture prostate cancer in his lifetime. About 220,800 subsidiary cases and 27,540 deaths from prostate cancer will be recorded this year, according to the American Cancer Society.
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